High Dose Intravenous Vitamin C (IVC)
Top Five Facts about IVC (High Dose Intravenous Vitamin C)
- Vitamin C was first suggested as a tool for cancer treatment in the 1950s.
- Riordan et al. demonstrated the likelihood that Vitamin C was an effective anti-tumor therapy as long as high enough concentrations of it could be achieved inside the tumor(s).
- These researchers also concluded that oral Vitamin C supplementation was unlikely to produce blood levels of Vitamin C high enough to have a direct killing effect on a given tumor.
- Since cancer patients are often depleted of vitamin C, replenishment may improve immune system function and enhance patient health and well-being.
- High dose IVC is a chemotherapeutic agent that can be given in conjunction with conventional cancer treatments.
It is theorized that vitamin C, when administered in high doses by intravenous (I.V.) infusions, can kill cancer cells. Vitamin C interacts with iron and other metals to create hydrogen peroxide. In high concentrations, hydrogen peroxide damages the DNA and mitochondria of cancer cells and shuts down their energy supply and kills them outright.
It is suggested that it is selectively toxic. No matter how high the concentration, Vitamin C does not harm healthy cells.
Do not attempt to use this treatment by yourself. This treatment must be used under the direction of cancer experts who are based at a clinic.
Two-time Nobel Prize winner Linus Pauling, along with Dr. Ewen Cameron of Scotland, did a scientific study suggesting that Vitamin C, given by I.V., could extend the life of advanced cancer patients six-fold.
“Vitamin C is thought to act as a pro-oxidant inside the cell in high concentration, and some hydrogen peroxide is formed which is rapidly disposed of by catalase in a normal cell,” said Dr. William Wassell. “Since cancer cells have a deficiency or lack entirely of catalase the peroxides kill the [cancer] cell.”
In cancer, Riordan et al. (1995) demonstrated the likelihood that Vitamin C was an effective anti-tumor therapy as long as high enough concentrations of it could be achieved inside the tumor(s). These researchers also concluded that oral Vitamin C supplementation was unlikely to produce blood levels of Vitamin C high enough to have a direct killing effect on a given tumor.
Later, in studying a certain line of cancer cells and the ability of Vitamin C to kill those cancer cells, Casciari et al. (2001) demonstrated this point. They showed that the rapid intravenous infusion of Vitamin C as sodium ascorbate in combination with alpha-lipoic acid was effective in reaching Vitamin C levels that were toxic to the cancer cells. They also showed that a fat-soluble analogue of Vitamin C, phenyl-ascorbate, was able to kill cancer cells effectively at a dose roughly three times lower than seen with unaltered Vitamin C.
Vitamin C was first suggested as a tool for cancer treatment in the 1950s. Its role in collagen production and protection led scientists to hypothesize that ascorbate replenishment would protect normal tissue from tumor invasiveness and metastasis (McCormick, 1959; Cameron, et al., 1979). Also, since cancer patients are often depleted of vitamin C (Hoffman, 1985; Riordan, et al., 2005), replenishment may improve immune system function and enhance patient health and well-being (Henson, et al., 1991).
Cameron and Pauling observed four-fold survival times in terminal cancer patients treated with intravenous ascorbate infusions followed by oral supplementation (Cameron & Pauling, 1976). However, two randomized clinical trials with oral ascorbate alone conducted by the Mayo clinic showed no benefit (Creagan, et al., 1979; Moertel, et al., 1985). Most research from that point on focused on intravenous ascorbate. The rationales for using intravenous ascorbate infusions (IVC) to treat cancer:
- Plasma ascorbate concentrations in the millimolar range can be safely achieved with IVC infusions.
- At millimolar concentrations, ascorbate is preferentially toxic to cancer cells in vitro and is able to inhibit angiogenesis in vitro and in vivo.
- Vitamin C can accumulate in tumors, with significant tumor growth inhibition seen (in guinea pigs) at intra-tumor concentrations of 1 mM or higher.
- Published case studies report anti-cancer efficacy, improved patient well-being and decreased markers of inflammation and tumor growth.
- Phase I clinical studies indicate that IVC can be administered safely with relatively few adverse effects.
If large amounts of Vitamin C are presented to cancer cells, it is suggested that large amounts will be absorbed. In these unusually large concentrations, the antioxidant Vitamin C will start behaving as a pro-oxidant as it interacts with intracellular copper and iron. This chemical interaction produces small amounts of hydrogen peroxide.
It is theorized that, because the cancer cells are relatively low in the intracellular antioxidant enzyme catalase, the high dose Vitamin C induction of peroxide will continue to build up until it eventually lysis the cancer cell from the inside out. This effectively makes high dose IVC a chemotherapeutic agent that can be given in conjunction with conventional cancer treatments. Based on the work of several Vitamin C pioneers before him, Dr. Riordan was able to show that Vitamin C was selectively toxic to cancer cells if given intravenously. This research was reproduced and published by Dr. Mark Levine at the National Institutes of Health.
Only markedly higher doses of Vitamin C will selectively build up as peroxide in the cancer cells to the point of acting in a manner similar to chemotherapy. These tumor-toxic dosages can only be obtained by intravenous administration.
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