The cachexia (hydrazine sulphate) treatment
First, let's take a look at one particular theory about a cancer cell:
The 1931 Nobel laureate in medicine, Otto Warburg, Ph.D., first discovered that cancer cells have a fundamentally different energy metabolism compared to healthy cells. The crux of his Nobel thesis was that malignant tumors frequently exhibit an increase in anaerobic glycolysis — a process whereby glucoseA type of sugar; the chief source of energy for living organisms. is used as a fuel by cancer cells with lactic acid as an anaerobic by-product — compared to normal tissues. The large amount of lactic acid produced by this fermentation of glucose from cancer cells is then transported to the liver. This conversion of glucose to lactate generates a lower, more acidic pH in cancerous tissues as well as overall physical fatigue from lactic acid build-up. Thus, larger tumors tend to exhibit a more acidic pH.
This inefficient pathway for energy metabolism yields only 2 moles of adenosine triphosphate (ATP) energy per mole of glucose, compared to 38 moles of ATP in the complete aerobic oxidation of glucose. By extracting only about 5 percent (2 vs. 38 moles of ATP) of the available energy in the food supply and the body's calorie stores, the cancer is “wasting” energy, and the patient becomes tired and undernourished. This vicious cycle increases body wasting. It is one reason why 40 percent of cancer patients die from malnutrition, or cachexiaWeakness and wasting of the body due to severe chronic illness, also known as Wasting Syndrome, is a sign of diseases, such as advanced chronic obstructive pulmonary disease (COPD), AIDS, cancer, or heart failure.. Hence, cancer therapies should encompass regulating blood-glucose levels via diet, supplements, non-oral solutions for cachectic patients who lose their appetite, medication, exercise, gradual weight loss and stress reduction.
What can we learn from this theory?
- Cancer cells ferment glucose, a very inefficient mechanism.
- As part of this fermentation, cancer cells create lactic acid.
- This lactic acid goes to the liver.
- This process also makes a cancer cell very acidic (which is why cancer cells do not like to be alkaline).
- Cancer cells are very inefficient at processing glucose, only about 5 percent as efficient, meaning they “waste” energy.
- This wasted energy causes the cancer patient to become tired and malnourished.
- This excessive use of glucose by a cancer cell is actually part of the process whereby cancer cells actually “steal” glucose from normal cells (cancer cells also steal nutrients from normal cells).
- This means normal cells can literally starve to death, creating malnutrition and death.
Note the vicious cycle in the above list. It is this cycle that causes the body to literally waste away. But there is another key part of the cycle: Large tumours produce much lactic acid that is reconverted in the liver into glucose in a process that consumes much energy. It is of positive benefit to block this conversion by taking hydrazineAn inorganic chemical compound with the formula N2H4. It is a colorless liquid with an ammonia-like odor. It is an extremely toxic and dangerously unstable liquid derived from the same industrial chemistry processes that manufacture ammonia. sulphate or [cesium] chloride. The main benefits are weight gain and increased energy that are especially important in the last stage of cancer, called cachexia. In addition, tumour growth may be inhibited, in some instances tumours gradually disappeared.
Now we see another key part of the cycle, the liver converts the lactic acid back into glucose, and guess who eats much of this glucose? The cancer cells. But the conversion by the liver of the lactic acid back into glucose also takes large amounts of energy.
Thus we can see a simplified picture of the entire cycle:
- The cancer cells ferment massive amounts of glucose, which consumes energy,
- They process the glucose with fermination, which is very inefficient,
- A byproduct of this fermentation is lactic acid,
- This lactic acid then goes into the liver,
- The liver then converts this lactic acid back into glucose, consuming even more energy
- Much of this glucose is consumed by the cancer cells and the cycle starts over.
Cachexia is the wasting away of the cancer patient's body. The person is reduced to skin and bones, while the cancer continues growing vigorously. What is happening is that the cancer incompletely metabolizes glucose, turning it into lactic acid. … This lactic acid (if it reaches the bloodstream) travels to the liver where it is converted back into glucose by a procedure that consumes an enormous amount of the body's energy. This happens over and over again as the cancer grows and the rest of the body wastes away. Hydrazine sulphate blocks a key enzymeA protein that speeds up chemical reactions in the body. in the liver that allows lactic acid to be converted into glucose.
Cachexia: in a chronic infection/chronic disease, the patient's temperature rises, the CD4 count drops below the CD8 count, and the appetite wanes until the patient develops pathological anorexia. The body still needs nourishment, so it begins breaking down its fat stores, the process of glycogenesis, and also begins to break down proteins to deliver these sugar precursors, the ones produced by glycogenesis, to the body. The metabolism of tumor/cancer cells is much less efficient than those of normal cells: normal cells metabolize aerobically, using oxygen, which is 15 times more efficient than cancer cells that metabolize anaerobically, through a process of fermentation.
Fermentation, being less efficient, requires much more sugar than aerobically metabolizing cells. Additionally, the metabolism rate of a tumor is much higher than that of normal cells, so the amount of sugar needed is still greater. Eventually the patient dies trying to feed the tumor. Starvation is the major cause of death in cancer and AIDS patients.
In short, when the person quits eating, the body starts to eat itself in order to feed the cancer cells.
Lactic acid build-up induces an acid build-up within the cell, which now causes changes in the DNA of the cell to promote unlimited reproduction. In other words, the cancer feeds itself in an acid environment. … Another potential way to starve the cancer then is to interfere with the liver's ability to produce glucose from lactic acid (the enzyme is called phosphoenolpyruvate carboxykinase) through hydrazine sulphate. Again, the specific agent is not the emphasis but rather the conceptual approach to altering the tissue environment.
Comments on weight loss
Before going any further, it is important to make a distinction. When a person first starts a typical alternative cancer treatment, it is recommended to change in their dietary habits. The person should go from a Western meat and sugar based diet to a special type of vegan diet. This change in diet, by itself, will typically cause a person to lose weight. Thus, just because a person who goes on an alternative cancer diet loses weight does not mean that their body is in the cachexia cycle.
In other words, even if a person did not have cancer, if they made such a sudden change in diet they would lose weight. In fact, a vegan diet is a good weight loss diet even for people who do not have cancer.
Cachexia is different. With cachexia the body is literally eating itself. It is eating the person's muscles, fat and many other parts of the body. Thus, the patient must keep in mind the difference between a “normal” loss of weight and an “abnormal” loss of weight. One key to determining whether a loss in weight is cachexia or not is knowing when the uncontrollable weight loss started. If it started before the switch to alternative treatments, it might be cachexia. However, if the weight loss started at the same time as the switch to an alternative cancer diet, most likely it is not cachexia, unless the weight loss continues for more than a few weeks. There are other things that cause uncontrolled weight loss. For example, in some rare cases hormone balance defects may cause an unstoppable loss of weight.
Also, in some cases the person loses their will to eat, usually due to being sick all of the time. This leads to a loss of appetite and a loss of weight. While this is technically not cachexia, it almost certainly will lead to cachexia. Cancer cells will eat, and they will eat the person's body if necessary.
Hydrazine sulphate theory
Of all of the alternative treatments for cachexia, perhaps hydrazine sulphate is the best known. Hydrazine sulphate is theorized to work by stopping the cycle mentioned above. Hydrazine sulphate “interrupts the ability of the liver to convert lactic acid from tumors into glucose thereby helping to starve the tumors and inhibit their ability to metastasize.”
Overall gluconeogenesis is stimulated when cancer is present. Gluconeogenesis requires a great deal of energy and excessive gluconeogenesis is thought to be a significant factor that contributes to cancer cachexia (Gold, 1968). Dr. Joseph Gold recognized in the 1960’s that metabolic strategies that inhibited the enzyme phosphoenol pyruvate carboxykinase (PEP-CK) would reduce gluconeogenesis and decrease the severity of cachexia (Gold, 1968). Dr. Gold after testing a series of compounds found that hydrazine sulphate could effectively reduce excessive gluconeogenesis in cancer (Gold, 1974, 1981).
By stopping the liver from converting the lactic acid into glucose breaks the cachexia cycle.
Dr. Joseph Gold looked at the chemical process of glycogenesis and determined that, if he inhibited the PEP CK enzyme (much too large a word for anyone to try to pronounce), he could stop the process. Voila, he came up with hydrazine sulphate, a substance that is made cheaply, simple to use, fuels military rockets and shrinks tumors. In his early animal studies, Dr Gold showed that, in greater than fifty percent of cancerous animals, he was able to stop the process of glycogenesis, end the cachexia, and the animals began gaining weight. With sugars cut off to the tumor, the tumors began shrinking.
One option to help hydrazine sulphate stop this cycle is alkalinity. Cesium chloride (and a few other minerals), the most common substance to make cancer cells alkaline in an alkaline treatment program, has been theorized by Dr. A. Keith Brewer, Ph.D., to get into cancer cells, when other nutrients cannot. The claims state that cesium chloride:
- makes the cancer cell alkaline,
- limits the intake of glucose into the cell (thus starving the cell),
- neutralizes the lactic acid (which is actually what causes the cell to multiply uncontrollably and eventually kills the cell) and makes it nontoxic, and
- stops the fermentation process, which is a second affect of limiting the glucose (fermentation is what creates lactic acid in the first place).
In other words, cesium chloride may break the cycle in several different ways.
But this is the important point: Hydrazine sulphate may block the cachexia cycle in the liver and cesium chloride blocks the cachexia cycle in the cancer cells.
Hydrazine sulphate is an MAOI (Momoamine Oxidase Inhibitor). It inhibits an enzyme that breaks down monoamines (serotonin, norepinephrine, and dopamine), those brain chemicals that make us happy. MAO inhibitors have been used as antidepressants. However, MAOs have another job in the body: they metabolize tyramine, an amino acid. When taking an MAO inhibitor, tyramine is not broken down, and eating foods with tyramine can raise your blood pressure and heart beat dramatically and cause the worst headache you've ever experienced. This is a very dangerous condition, especially for someone already battling cancer. Most of the foods containing tyramine are not on the cancer diet plan, and you should be avoiding them anyway.
Foods containing tyramine are (mainly) aged, fermented, or pickled, such as most cheeses (except cottage cheese, cream cheese, and fresh Mozzerlla), lunch meats, hot dogs, yogurt, wines and beers. Here is a pretty good list of foods that contain tyramine:
(Note: there is absolutely no accurate list of what foods have tyramine. One site says raspberries and grapes do have them, and another site says they don't. The bottom line is if the cancer patient gets headaches, then it is highly likely they are eating something with tyramine in it. )
Some foods that contain tyramine include:
- Barleygrass (perhaps the highest percentage of all according to Dr. Duke, but he doesn't list other grasses), which would exclude all barley supplements,
- Dry and fermented sausage (bologna, salami, pepperoni, corned beef, and liver),
- pickled herring and salted dried fish,
- broad beans and pods (lima, fava beans, lentils, snow peas, and soy beans),
- meat extracts,
- yeast extracts/brewer's yeast, beer and ale, red wine (chianti, burgundy, sherry, vermouth),
- fruits listed by Dr. Duke (oranges, tangerines, lemon, grapefruit),
- some fruits (bananas, avacados, canned figs, raisins, red plums, raspberries, pinapples),
- cultured dairy products (buttermilk, yogurt, and sour cream),
- caffeine (coffee, tea, and cola drinks),
- white wine, port wines, distilled spirits,
- soy sauce, miso, peanuts, almonds,
- beef or chicken liver, herring,
- meat tenderizer, MSG (Accent),
- pickles, and
- pumpkin seeds.
In general, any high protein food that has undergone aging should be suspect of containing tyramine. Also, any over-the-counter cold or allergy remedy should also be avoided.
Hydrazine sulphate is a monoamine oxidase inhibitor and the following should not be used during hydrazine therapy: tranquilizers or sedatives in doses greater than 100 mg per day, especially benzodiazepines and phenothiazines should be avoided, also antihistamines, alcohol and other agents that depress the central nervous system such as morphine. Also vitamin B6 should not be taken. Foods high in tyramine must be avoided. These are aged and fermented products such as most cheeses, cured meats or fish, sour cream and yoghurt, tofu and tempeh, bouillon cubes, sauerkraut, pickles and yeast extracts. Also restricted are broad beans, avocados, bananas, raisins, figs, dates and dried fruit in general as well as overripe fruit.
Warning from Dr. Gold, developer of Hydrazine Sulphate:
HS is an irreversible and potent MAO (monoamine oxidase) inhibitor, a class of compounds that can have potentially deadly interactions with other drugs. For over three decades it has been known that central nervous system depressants — such as barbiturates, tranquilizers and alcohol — are incompatible with MAO inhibitors and use of the two together could result in extremely dangerous effects.
In addition to the Cellect-Budwig protocol, the following things should not be taken with Hydrazine Sulphate:
- alcoholic beverages
- barbiturates and tranquilizers (e.g. Thorazine, Compazine, Xanax, Valium, Dalmane, Ativan, Restoril, Halcion, Nembutal and Seconal, to name but a few)
- sedatives in doses greater than 100 mg per day, especially benzodiazepines and phenothiazines
- other agents that depress the central nervous system, such as morphine
- foods with tyramine
- Vitamin B6
- Vitamin C in daily doses above 250 mg (from all sources)
Of course, in addition to all of these things, foods high in glucose should be avoided.
Using hydrazine sulphate with other treatments
Hydrazine sulphate is frequently used with other alternative cancer treatments. These other treatments may have a list of foods, or supplements that contain condensed foods, that can be used with them. When looking at these lists of foods, or supplements with condensed foods in them, make sure you keep in mind that hydrazine sulphate has a long list of foods that cannot be taken with it. For example, both the Cesium Chlroride Protocol and Calcium Protocol lists high doses of Vitamin C.