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In Cancer: A Second Opinion, Issels describes the treatment that produced the most remarkable, independently verified cure rate in medical history.

Ralph Moss, PhD, a young and eager science writer, was hired by Sloan-Kettering's public relations department in 1974, to help brief the American public on the center's contribution to the War On Cancer. Shortly after starting his position, Moss befriended one of the center's oldest and leading research scientists, Dr. Kanematsu Sugiura—an original co-founder of chemotherapy.